![]() ![]() The epicardium is a single layer of mesothelial cells that attaches to and spreads over the myocardium beginning at E9.5 in the mouse. As adherens junctions are the primary sites of epithelial cell attachment, they are essential for maintaining epithelial sheet integrity and apical-basal polarity, and one necessary component of the adherens junction is β-catenin ( Yap et al., 1997). Par6, aPKC and Par3 are part of the polarity complex that establishes apical-basal polarity ( Kemphues et al., 1988 Muller and Wieschaus, 1996), directs asymmetric cell division ( Cheng et al., 1995 Kemphues et al., 1988), and positions adherens junctions during epithelial development ( Harris and Peifer, 2004). ![]() The establishment of cell polarity is important for many biological processes including asymmetric cell division and directed cell migration. ![]()
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